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Membrane-incorporated PUFAs serve as primary targets for ROS-mediated oxidation, with their oxidative susceptibility increasing proportionally to the number of conjugated double bonds (Rouzer and Marnett, 2003), following the initiation of oxidation, free radicals exhibit dual propagation mechanisms: intramolecular migration within lipid bilayers or intermolecular chain reactions amplifying oxidative damage (Samovich et al., 2024)

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704 Within this pathway, lipoprotein receptor-related protein 5 (LRP5) serves as a significant coreceptor for signal transduction, facilitating Wnt signaling and further promoting cancer progression by increasing aerobic glycolysis